Tuesday, April 9, 2013

Genome Stability and Transgenerational Mutations Caused by Radiation

'Genome Stability: Transgenerational Mutation by Radiation' by Yuri E. Dubrova1,2, Mark Plumb3, Bruno Gutierrez1, Emma Boulton3 & Alec J. Jeffreys1 Nature 405, 37 (4 May 2000) | doi:10.1038/35011135 http://www.nature.com/nature/journal/v405/n6782/abs/405037a0.html

[Excerpted] Parental exposure to ionizing radiation increases the frequency of germline mutations detectable in the next generation1. Parental exposure can also increase the rate of mutation in somatic cells2, 3 and confer a predisposition to cancer4, 5, 6 in offspring, suggesting that there could be an indirect effect of radiation on somatic genome stability that is transmissible through the germ line of the irradiated parents. 

We have found that this indirect effect extends to the germ line of unexposed first-generation offspring in mice, as revealed by an increased instability of repeat-DNA sequences in their descendants. [end]

Majia here: Fuku, among other sources of ionizing radiation, is going to increase the instability of the next generation's genome.


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