Saturday, May 15, 2021

3 Hypotheses Regarding Covid-19 Infections in "Developed" Economies this Fall-Winter 2021-2022


THREE HYPOTHESES Regarding Covid-19 in Developed Countries in Fall-Winter 2021-2022

Hypothesis 1 – “Institutional Response”: Vaccines will work – they are showing positive results. Vaccinated people will fare better than non-vaccinated and "break-through" infections will be rare and non-consequential.

Hypothesis 2 - The vaccines will work against variants but vaccination during the pandemic, especially among immune compromised people, will increase vaccine immune escape, leading to more breakthrough infections among the vaccinated but also more severe disease among the unvaccinated, as occurs during vaccination of chickens during outbreaks of Marek’s Disease – See https://www.pbs.org/newshour/science/tthis-chicken-vaccine-makes-virus-dangerous

Hypothesis 3 - Vaccinated individuals will experience antibody enhancement effect after exposure to variants with immune escape potential, as occurred with previous experiments with SARS vaccines. Vaccinated individuals will be worse off when confronting variants with immune escape potential than unvaccinated populations.

EVIDENCE FOR VACCINE EFFICACY

The empirical evidence published in Journal of American Medicine and other similar established journals finds the vaccine has been effective in preventing hospitalizations as compared to unvaccinated control populations. 

However, the data so far are pretty much restricted to D and G SARS-CoV-2 variants that the vaccines were designed directly to address. One sample study:

  • Angel Y, Spitzer A, Henig O, et al. Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers. JAMA. Published online May 06, 2021. doi:10.1001/jama.2021.7152


MECHANISM FOR POTENTIAL ANTIBODY ENHANCEMENT

"Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which binding of a virus to suboptimal antibodies enhances its entry into host cells, followed by its replication ...." (Wikipedia)

Does the SARS-CoV-2 spike protein produce antibody-dependent enhancement? 

New research indicates the spike protein adversely affects vascular system even in the absence of the rest of the virus. Repeated exposures to spike protein increase likelihood of stimulating an auto-immune response against platelets.

This problem adversely affected efforts to create a SARS vaccine:

  • Tseng CT, Sbrana E, Iwata-Yoshikawa N, Newman PC, Garron T, Atmar RL, Peters CJ, Couch RB. 2012. Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus. PLoS One. 2012;7(4):e35421. doi: 10.1371/journal.pone.0035421.

However, whether this same problem affects SARS-CoV-2 vaccines is unknown at this point. 

There have been many adverse events linked to vaccines but do they derive from the spike protein or from the vaccine vectors (e.g., adenovirus) or preservatives?

Competing view points below:


EVIDENCE FOR VACINE-INDUCED ANTIBODY ENHANCEMENT EFFECT

Ciabattini, A., Garagnani, P., Santoro, F. et al. Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population. Semin Immunopathol 42, 619–634 (2020). https://doi.org/10.1007/s00281-020-00821-0

Talia Kustin, Noam Harel, Uriah Finkel, Shay Perchik, Sheri Harari, Maayan Tahor, Itamar Caspi, Rachel Levy, Michael Leschinsky, Shifra Ken Dror, Galit Bergerzon, Hala Gadban, Faten Gadban, Eti Eliassian, Orit Shimron, Loulou Saleh, Haim Ben-Zvi, Doron Amichay, Anat Ben-Dor, Dana Sagas, Merav Strauss, Yonat Shemer Avni, Amit Huppert, Eldad Kepten, Ran D. Balicer, Doron Nezer, Shay Ben-Shachar, Adi Stern. Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals. doi: https://doi.org/10.1101/2021.04.06.21254882 

Yuyang Lei , Jiao Zhang, Cara R. Schiavon , Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S. Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X.-J. Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang, Zu-Yi Yuan, John Y-J. Shyy Originally published 31 Mar 2021. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circulation Research. 2021;128:1323–1326. https://doi.org/10.1161/CIRCRESAHA.121.318902

Israel examining heart inflammation cases in people who received Pfizer COVID shot
https://www.reuters.com/world/middle-east/israel-examining-heart-inflammation-cases-people-who-received-pfizer-covid-shot-2021-04-25/

Vaccination and Guillain-Barre
https://www.yahoo.com/finance/news/ema-safety-committee-reviews-heart-195610039.html

Vandana SinghFri, May 7, 2021 EMA Safety Committee Reviews Heart Inflammation, Rare Nerve Disorder Reports After Pfizer, AstraZeneca COVID-19 Shots, https://www.yahoo.com/finance/news/ema-safety-committee-reviews-heart-195610039.html

Pfizer, AstraZeneca COVID vaccines probed in Europe after reports of heart inflammation, rare nerve disorder https://www.fiercepharma.com/pharma/europe-s-drug-regulator-evaluates-reports-heart-inflammation-rare-nerve-disorder-covid-19

Pentagon Tracking 14 Cases of Heart Inflammation in Troops After COVID-19 Shots 26 Apr 2021 https://www.military.com/daily-news/2021/04/26/pentagon-tracking-14-cases-of-heart-inflammation-troops-after-covid-19-shots.html

Denmark drops J&J Vaccine over blood clot concerns. The Financial Times
https://www.ft.com/content/3a89e349-0c08-4ee7-908e-20037b016cc6


EVIDENCE FOR VIRUS-INDUCED ANTIBODY ENHANCEMENT EFFECT

We know the SARS-CoV-2 virus produces all of the terrible effects linked to vaccines but in MUCH GREATER FREQUENCY.

So, the question of benefits versus risks of vaccinating during this pandemic with "experimental" vaccines is still very much unsettled?

We can re-evaluate the evidence in January 2021.

 

Wednesday, May 12, 2021

Chernobyl Fissions and Fukushima Simmers: Nuclear is the Road to our Extinction

 

Nuclear "accidents" NEVER END, as well described by Dr. Helen Caldicott

The damaged nuclear fuel remaining at the center of the Chernobyl nuclear catastrophe is increasingly hot with fissile activity:

Sommerlad, Joe. (2021, May 12). Nuclear reactions found smoldering at Chernobyl ‘like embers in a barbecue’. The Independent. https://www.independent.co.uk/news/world/europe/chernobyl-explosion-nuclear-radiation-ukraine-b1845672.html

Ukraine scientists concerned by 40 per cent spike in neutron emissions since 2016 in inaccessible chamber.

BIG QUESTION: Will escalating fission activity create an enduring chain reaction capable of producing a nuclear explosion or will it be a slower process of disseminating life-destroying chemicals and atoms?


Fukushima Daiichi's damaged but still active fuel appears to be taking the second course. Japan has decided to dump water used to cool Daiichi's ruined and broken debris collected over the last decade. That water is still quite contaminated with TRITIUM and other nasty radioactive elements. Japan had trouble with water filtration for years.

And I would be remiss to mention the Hanford Nuclear Site, which is a similar but different slow moving nuclear apocalypse.

It's all going into the Pacific Ocean and local aquifers. 

 

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GENETICS, HUMAN HEALTH AND RADIATION

Burdening the species with genetic mutations: http://majiasblog.blogspot.com/2012/05/burdening-species-with-genetic.html

Mutations and Germ Line Mosaicism: http://majiasblog.blogspot.com/2012/05/mutations-germ-line-mosaicism.html

Somatic or genetic effects? http://majiasblog.blogspot.com/2012/07/somatic-or-genetic-effects.html

Ionizing radiation and germ line cell damage: http://majiasblog.blogspot.com/2012/02/ionizing-radiation-and-germ-cell-damage.html

Discouraged: http://majiasblog.blogspot.com/2012/06/discouraged.html

Children and Radiation http://majiasblog.blogspot.com/2012/07/children-and-ionizing-radiation.html

Autism and radiation http://majiasblog.blogspot.com/2012/08/autism-and-radiation.html

Studying autism and radiation: http://majiasblog.blogspot.com/2013/06/autism-and-environment-lets-study.html

How to Bias Studies on Radiation: http://majiasblog.blogspot.com/2012/07/how-to-bias-studies-on-biological.html

Radiation dose history: http://majiasblog.blogspot.com/2012/03/estimating-dose-and-history-of.html

Run when you hear no immediate danger: http://majiasblog.blogspot.com/2012/06/run-when-you-hear-no-immediate-danger.html

Internal emitters: http://majiasblog.blogspot.com/2012/05/on-internal-emitters.html