Saturday, May 15, 2021

3 Hypotheses Regarding Covid-19 Infections in "Developed" Economies this Fall-Winter 2021-2022


THREE HYPOTHESES Regarding Covid-19 in Developed Countries in Fall-Winter 2021-2022

Hypothesis 1 – “Institutional Response”: Vaccines will work – they are showing positive results. Vaccinated people will fare better than non-vaccinated and "break-through" infections will be rare and non-consequential.

Hypothesis 2 - The vaccines will work against variants but vaccination during the pandemic, especially among immune compromised people, will increase vaccine immune escape, leading to more breakthrough infections among the vaccinated but also more severe disease among the unvaccinated, as occurs during vaccination of chickens during outbreaks of Marek’s Disease – See https://www.pbs.org/newshour/science/tthis-chicken-vaccine-makes-virus-dangerous

Hypothesis 3 - Vaccinated individuals will experience antibody enhancement effect after exposure to variants with immune escape potential, as occurred with previous experiments with SARS vaccines. Vaccinated individuals will be worse off when confronting variants with immune escape potential than unvaccinated populations.

EVIDENCE FOR VACCINE EFFICACY

The empirical evidence published in Journal of American Medicine and other similar established journals finds the vaccine has been effective in preventing hospitalizations as compared to unvaccinated control populations. 

However, the data so far are pretty much restricted to D and G SARS-CoV-2 variants that the vaccines were designed directly to address. One sample study:

  • Angel Y, Spitzer A, Henig O, et al. Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers. JAMA. Published online May 06, 2021. doi:10.1001/jama.2021.7152


MECHANISM FOR POTENTIAL ANTIBODY ENHANCEMENT

"Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which binding of a virus to suboptimal antibodies enhances its entry into host cells, followed by its replication ...." (Wikipedia)

Does the SARS-CoV-2 spike protein produce antibody-dependent enhancement? 

New research indicates the spike protein adversely affects vascular system even in the absence of the rest of the virus. Repeated exposures to spike protein increase likelihood of stimulating an auto-immune response against platelets.

This problem adversely affected efforts to create a SARS vaccine:

  • Tseng CT, Sbrana E, Iwata-Yoshikawa N, Newman PC, Garron T, Atmar RL, Peters CJ, Couch RB. 2012. Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus. PLoS One. 2012;7(4):e35421. doi: 10.1371/journal.pone.0035421.

However, whether this same problem affects SARS-CoV-2 vaccines is unknown at this point. 

There have been many adverse events linked to vaccines but do they derive from the spike protein or from the vaccine vectors (e.g., adenovirus) or preservatives?

Competing view points below:


EVIDENCE FOR VACINE-INDUCED ANTIBODY ENHANCEMENT EFFECT

Ciabattini, A., Garagnani, P., Santoro, F. et al. Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population. Semin Immunopathol 42, 619–634 (2020). https://doi.org/10.1007/s00281-020-00821-0

Talia Kustin, Noam Harel, Uriah Finkel, Shay Perchik, Sheri Harari, Maayan Tahor, Itamar Caspi, Rachel Levy, Michael Leschinsky, Shifra Ken Dror, Galit Bergerzon, Hala Gadban, Faten Gadban, Eti Eliassian, Orit Shimron, Loulou Saleh, Haim Ben-Zvi, Doron Amichay, Anat Ben-Dor, Dana Sagas, Merav Strauss, Yonat Shemer Avni, Amit Huppert, Eldad Kepten, Ran D. Balicer, Doron Nezer, Shay Ben-Shachar, Adi Stern. Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals. doi: https://doi.org/10.1101/2021.04.06.21254882 

Yuyang Lei , Jiao Zhang, Cara R. Schiavon , Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S. Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X.-J. Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang, Zu-Yi Yuan, John Y-J. Shyy Originally published 31 Mar 2021. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circulation Research. 2021;128:1323–1326. https://doi.org/10.1161/CIRCRESAHA.121.318902

Israel examining heart inflammation cases in people who received Pfizer COVID shot
https://www.reuters.com/world/middle-east/israel-examining-heart-inflammation-cases-people-who-received-pfizer-covid-shot-2021-04-25/

Vaccination and Guillain-Barre
https://www.yahoo.com/finance/news/ema-safety-committee-reviews-heart-195610039.html

Vandana SinghFri, May 7, 2021 EMA Safety Committee Reviews Heart Inflammation, Rare Nerve Disorder Reports After Pfizer, AstraZeneca COVID-19 Shots, https://www.yahoo.com/finance/news/ema-safety-committee-reviews-heart-195610039.html

Pfizer, AstraZeneca COVID vaccines probed in Europe after reports of heart inflammation, rare nerve disorder https://www.fiercepharma.com/pharma/europe-s-drug-regulator-evaluates-reports-heart-inflammation-rare-nerve-disorder-covid-19

Pentagon Tracking 14 Cases of Heart Inflammation in Troops After COVID-19 Shots 26 Apr 2021 https://www.military.com/daily-news/2021/04/26/pentagon-tracking-14-cases-of-heart-inflammation-troops-after-covid-19-shots.html

Denmark drops J&J Vaccine over blood clot concerns. The Financial Times
https://www.ft.com/content/3a89e349-0c08-4ee7-908e-20037b016cc6


EVIDENCE FOR VIRUS-INDUCED ANTIBODY ENHANCEMENT EFFECT

We know the SARS-CoV-2 virus produces all of the terrible effects linked to vaccines but in MUCH GREATER FREQUENCY.

So, the question of benefits versus risks of vaccinating during this pandemic with "experimental" vaccines is still very much unsettled?

We can re-evaluate the evidence in January 2021.

 

8 comments:

  1. The trumpists canceled themselves. They spontaneously exposed their great leader, as the fraud chicken hawk he is. Trump sacrificed their lives and the people who they killers for nothing as a villonous , cold blooded killer.. They reduced themselves to irrational abominations . They Dishonored themselves. For those left on the bloody sacrifice alter to languish in the system, they now know their idiot leader is a sadistic vile, criminal, nothing and idiot.

    Some truly stupid repuklikans continue to have a sick, sadomasochistic relationship for the thing . The more he criticizes them, the more they lick his boots. The judges are putting the capital murderers, in jail. They plead, that it was a once in a lifetime frenzy. Meanwhile Trump calls for more insurrection, which proves it wasn't temporary insanity and, is far more insidious and sociopathic, than a temporary loss of sanity and humanity. They will probably get less time, than what many black people are incarcerated for, with 20 year sentences.

    They need to pay their debt to society, as they would expect others to do, for what the have done. The more Trump, tells them they did not do enough for him to continue the bloody farce, the more they want to continue, to lick his shoes.

    ReplyDelete
  2. https://nuclear-news.net/2021/05/20/boris-johnsons-plan-for-more-nuclear-weapons-in-scotland-breaks-international-law/

    THIS IS WHY BORIS JOHNSON WANTED BREXIT. TO MAKE A KILLING IN THE STOCK MARKET OFF NUCLEAR LIKE TRUMP. BORIS JOHNSON WILL TOPPLE HIMSELF SOON. LIKE THE REPUKLIKANS CANCELLED THEMSELVES

    ReplyDelete
  3. I hear old JW yammering about prcog crime programs that started with nixon and honed under repugs and centrist for years. You could see Microsoft, Ellison, thiel, google, istael rubbing their hands together at the prospect in nineties. Its an ongoing project, that centrists and repukes love.
    We are already targeted and have been for a while.. We have been since richard nixon with his enemies lists and racist drug, forever wars. The oligarchy, the military w the mic, and wall street , are  like the three stooges. Con artists on a grand and deadly scale.

    The gang that couldn't shoot straight, with deadly consequences.  They continue to bumble along, with their puny panopticon of Artificial Intelligence-hot-crime-areas, in ghettos in cities. Areas far removed, from where the real societal destruction, is occuring.

    Their license plate readers, target the wrong people. The nsa inet tracking, sets us up for real nuclear war and, nuclear catastrophe.

    The bumbling pronuclear criminal,  BJ of the UK, used BREXIT as an excuse to increase the nuclear security totalitarian state at all levels in Britain. Scotlland will rebel soon.    The disheveled criminal, will topple itself, from it's nuclear stock market insanities.

    That is what, Archnuclear militarist,  befuddlefrik drump did. So stupid, he could not pull off the coup and con, that would have destroyed murica. The repuklikans are buzy, thuroughly cancelling�� them themselves,in the process

    ReplyDelete
  4. Bipartisan Panopticon

    I hear yammering, by so-called, civil-libertarians, about precog crime programs under review, by biden. It is nothing new.

    The modern nuclear-security, police- state, started with Oppenheimer after ww2. Think Japanese internment camps. It got worse in the fifties, when the USA nuked it s own citizens. Now there are unauthorized drones, by nuke plants. nuclear reactors that we that we do not need.. There is the threat of cyber-warfare.

    The over all scope of the matter is top-down and, affects policing at community levels. Just go to a state like New Mexico. You will see what I mean. Nixon honed it for years, with his war on drugs under repugs and centrists.

    You could see  Microsoft, Ellison, thiel,  google, The Pentagon, rubbing their hands together at the prospect in  the nineties of using AI, in policing. Its an ongoing project, that centrists and repukes love.

    We are  already  targeted and, have been for a while.. We have been since richard nixon with his enemies lists and racist drug,  forever wars.  The oligarchy, the  military w the mic,  and wall street , are  like the three stooges. Con artists on a grand and, deadly scale. 

    The gang that couldn't shoot straight, with deadly consequences.  They continue to bumble along, with their puny panopticon of Artificial Intelligence-hot-crime-areas, in ghettos in cities. Areas far removed, from where the real societal destruction, is occuring.

    Their license plate readers, target the wrong people. The nsa inet tracking, sets us up, for real nuclear war and, nuclear catastrophe.

    The bumbling pronuclear criminal,  BJ of the UK, used BREXIT as an excuse to increase the nuclear security totalitarian state, at all levels in Britain. More bombs, more nuke subs, more nuclear reactors, that have to be monitored.

    Scotland will rebel soon.    The disheveled criminal, will topple itself, from it's nuclear stock market-insanities.

    That is what, Archnuclear militarist,  befuddlefrik drump did. So stupid, he could not pull off the coup and con, that would have destroyed murica. The repuklikans are busy, thuroughly cancelling themselves,in the process

    ReplyDelete
  5. CDC studying reports of heart inflammation in young Covid vaccine recipients https://www.theguardian.com/world/2021/may/23/cdc-studying-reports-of-heart-inflammation-in-young-covid-vaccine-recipients?CMP=oth_b-aplnews_d-1

    ReplyDelete
  6. More likely an after effect of pathogen exposure

    ReplyDelete
  7. https://www.counterpunch.org/2021/05/21/chernobyl-alert-and-the-doomsday-clock/

    ReplyDelete
  8. Article: The Failed Bloody Fascist Coup of 2021 | OpEdNews
    https://www.opednews.com/articles/The-Failed-Bloody-Fascist-by-Wayne-Madsen-America_Coup_Coup-Attempt_Donald-Trump-Criminal-210524-624.html

    Who could stand to be in the same space as these people

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    OpEdNews Op Eds 5/24/2021 at 9:48 AM EDT
    The Failed Bloody Fascist Coup of 2021
    By Wayne Madsen     
    (Page 1 of 3 pages)  (View How Many People Read This)   1 comment

    'It's like a manhood thing for him.'
    'It's like a manhood thing for him.'
    (Image by Thomas Cizauskas from flickr)   Details   DMCA


    Had the coup plotters of January 6, 2021, been successful, today the United States would have been under the rule of dictator Donald Trump. The traitorous retired General Michael Flynn would be vice president and be granted by Trump with unlimited powers to order arrests, seize private property, and rule states and cities by decree. Political purges of the armed forces, state and local governments, the courts, and corporations would be de rigueur.

    It is now known that the director of the U.S. Secret Service tolerated the politicization of his agency under Trump to the point that agents, including those who are sworn to protect the president, vice president, and other designated "protectees," became full-blown MAGA-hatted racists and far-right partisans. For example, in December 2019, Trump appointed Deputy Assistant Director of the Secret Service Anthony Ornato, [a career civil service member, to the political post of Deputy Chief of Staff for Operations, a position that entailed Ornato assisting in Trump's re-election. Secret Service Director James Murray raised no objections to Ornato being tapped for such a political position. Murray continues to remain in his job under President Biden. And, as if that is not enough of a reason for concern, Ornato is back at the Secret Service as Assistant Director in the Office of Training. Homeland Security Secretary Alejandro Mayorkas, someone with close family ties to unsavory far-right Cuban exile organizations in south Florida, has made no move to dismiss either Ornato or Murray. It should be recalled that it was partly from this community of far-right Cuban expatriates that the plot to assassinate President John F. Kennedy in 1963 originated.

    Washington Post reporter Carol Leonnig has published a book on the Secret Service, titled "Zero Fail: The Rise and Fall of the Secret Service," that delves into the right-wing radicalization of the Secret Service. It now appears that some key members of the Secret Service were either in on the plot by Trump, Flynn, and others to overthrow the government on January 6 or were quiescent in withholding intelligence on the scope of the coup plan. In yet another example where Hollywood was able to foresee the role of a compromised Secret Service in a plot against the government, two movies that premiered in 2013, "Olympus Has Fallen," and "White House Down," respectively have as their plots a former Secret Service agent-turned-private contractor working with a hostile foreign intelligence service and a Presidential Detail Special Agent-in-Charge working with

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