50% of my household suffered severe adverse events from the Moderna vaccine. I only got the vaccine because I was threatened with being fired. See my post here:http://majiasblog.blogspot.com/2021/12/this-is-not-disinformation-lot-030b21a.html
The consequences for our compliance with this extortion haunt us today.
Moreover, we know many, many people who suffered auto-immune disease conditions after taking mRNA vaccines. We also know of two people who died from their "vaxxes." I've reviewed the failed cost-benefit analysis previously at this blog.
I have spent the last 3 years trying to understand what happened. I've learned that there are at least 4 known problems with the mRNA platform:
- The spike protein payload
- The lipid "nanoparticle" delivery system
- The synthetic mRNA - N1-methylpseudouridine used in mRNA
- Contaminants/Adulterants
Spike protein is
dangerous in and of itself. Lipid nanoparticle encased instructions for
your body engineering spike can persist for an unknown length of time
and get distributed across your body and bioaccumulate in organs! Worse - the lipid nanoparticles are themselves highly toxic!
LIPID NANOPARTICLE DELIVERY SYSTEM
I highly recommend the informative video here regarding nature and hazards of lipid nanoparticles used in mRNA vaccinations by Dr Robert Malone, whose work with mRNA makes him a very legitimate authority on this subject:
https://open.substack.com/pub/rwmalonemd/p/lipid-nanoparticles-a-regulatory?r=q89bo&utm_campaign=post&utm_medium=web
RELATED RESEARCH
Parhiz, H. et al., (2022). Added to pre-existing inflammation,
mRNA-lipid nanoparticles induce inflammation exacerbation (IE). Journal of
Controlled Release, 344, 50-61.
Current nucleoside-modified RNA lipid nanoparticle
(modmRNA-LNP) technology has successfully paved the way for the highest clinical efficacy data from
next-generation vaccinations against SARS-CoV-2 during the COVID-19 pandemic.
However, such modmRNA-LNP
technology has not been characterized in common pre existing inflammatory or immune-challenged
conditions, raising the risk of adverse clinical effects when administering modmRNA-LNPs in such
cases.
Herein, we induce an acute-inflammation model in mice with lipopolysaccharide
(LPS) intratracheally (IT), 1 mg kg-1, orintravenously (IV), 2 mg kg-1, and then IV administer
modmRNA-LNP, 0.32 mg kg-1, after 4 h, and screen for inflammatory markers, such as pro inflammatory
cytokines. ModmRNA-LNP at this dose caused no significant elevation of cytokine levels in naive
mice.
In contrast, shortly after LPS immune stimulation, modmRNA-LNP enhanced inflammatory
cytokine responses, Interleukin-6 (IL-6) in serum and Macrophage Inflammatory Protein 2 (MIP-2) in liver
significantly.
Our report identifies this phenomenon as inflammation exacerbation (IE), which was
proven to be specific to the LNP, acting independent of mRNA cargo, and was demonstrated to be
time- and dose-dependent. Macrophage depletion as well as TLR3 -/- and TLR4-/- knockout mouse
studies revealed macrophages were themmune cells involved or responsible for IE. Finally, we
show that pretreatment with anti-inflammatory drugs, such as corticosteroids, can
partially alleviate IE response in mice. Our findings characterize the importance of LNP mediated IE
phenomena in gram negative bacterial inflammation, however, the generalizability of modmRNA LNP
in other forms of chronic or acuteinflammatory and immune contexts needs to be addressed.
SYNTHETIC mRNA
According to a 2020 study (doi.org/10.1105/tpc.19.00639) the
biological relevance of pseudouridine in mRNA remains unclear so
downstream effects are not yet mapped:
Mingjia
Chen , Claus-Peter Witte, A Kinase and a Glycosylase Catabolize
Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine
Monophosphate Accumulation, The Plant Cell, Volume 32, Issue 3, March
2020, Pages 722–739, https://doi.org/10.1105/tpc.19.00639 This
same study observes a risk of toxicity from pseurdouridine:
Compromising pseudouridine catabolism leads to strong pseudouridine
accumulation and increased ΨMP content. ΨMP is toxic, causing delayed
germination and growth inhibition. More Research Needed to Assure
Safety, Especially with Cumulative Exposures.
SPIKE PROTEIN PAYLOAD ISSUES
Scientists from the Salk institute that found that the spike protein
alone, in the absence of the rest of the virus, can cause damage to
endothelial cells? Here is the citation and the link to the press release for your reference
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
Yuyang Lei , Jiao Zhang , Cara R. Schiavon, Ming He, Lili Chen, Hui
Shen, Yichi Zhang, Qian Yin , Yoshitake Cho , Leonardo Andrade , Gerald
S. Shadel , Mark Hepokoski, Ting Lei, Hongliang Wang, Jin hang, Jason
X.-J. Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang, Zu-Yi Yuan, John
Y-J. Shyy Originally published31 Mar
2021https://doi.org/10.1161/CIRCRESAHA.121.318902Circulation Research.
2021;128:1323–1326
Another
study finds that the spike protein, detached from the rest of the virus,
elicits cell signalling in human cells, which "may promote pulmonary
vacular remodeling and PAH [pulmonary arterial hypertension] as well as
other cardiovascular complications":
Yuichiro J. Suzuki1,* and Sergiy G. Gychka
SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells:
Implications for Possible Consequences of COVID-19 Vaccines. Vaccines
2021, 9(1), 36; https://doi.org/10.3390/vaccines9010036
CONTAMINANTS
Dr.
Malone, in the video linked above, explains how failures in mRNA
vaccine manufactoring are resulting in concerning DNA contamination. The
production process is not "clean," as an example from Japan
illustrates.
August
28, 20213:38 Two die in Japan after shots from suspended Moderna
vaccines - Japan govt Reuters
https://www.reuters.com/business/healthcare-pharmaceuticals/two-die-japan-after-shots-suspended-moderna-vaccines-japan-govt-2021-08-28/
TOKYO, Aug 28 (Reuters) - Two people died after receiving Moderna Inc (MRNA.O)
COVID-19 vaccine shots that were among lots later suspended following
the discovery of contaminants, Japan's health ministry said on
Saturday.
RELATED POSTS
http://majiasblog.blogspot.com/2022/05/mrna-vaccines-linked-to-higher-cardio.html
http://majiasblog.blogspot.com/2022/04/fda-shuts-out-its-own-experts-in.html
http://majiasblog.blogspot.com/2022/03/thanatopolitics-and-vaccine-apartheid.html
http://majiasblog.blogspot.com/2021/08/what-is-going-on-no-public-health.html
http://majiasblog.blogspot.com/2021/06/spike-protein-blues.html
http://majiasblog.blogspot.com/2021/06/approval-mandatory-vaccine-mandates-for.html