Saturday, June 22, 2024

Disturbing Number of Cases of Neurodegenerative Disease in Canada

Troubling and inexplicable "progressive neurological illness" affecting young people in Canada. Known facts:

  • Up to 150 people documented, although actual number of cases could be greater
  • Impacts healthy young people with no previous relevant health history
  • Mechanism of biological action seems to be protein misfolding
  • Cases first announced Spring 2021
  • Government less than eager to investigate
  • Experts silenced

MEDIA COVERAGE (hat tip Naked Emperor for the Cecco & MacDiarmid cite)

Cecco, L. & MacDiarmid, C. (2024, June 21). Second Canadian scientist alleges brain illness investigation was shut down. The Guardian. https://www.theguardian.com/world/article/2024/jun/21/second-canadian-scientist-alleges-brain-illness-investigation-was-shut-down?utm_source=substack&utm_medium=email

...This month, the Guardian reported that another leading federal scientist, Michael Coulthart, had alleged he had been barred from investigating the cluster of unexplained illnesses.

Coulthart, a microbiologist who heads Canada’s Creutzfeldt-Jakob Disease Surveillance System, wrote in a leaked email that he believed an “environmental exposure – or a combination of exposures – is triggering and/or accelerating a variety of neurodegenerative syndromes”, with people seemingly susceptible to different protein misfolding ailments including Alzheimer’s and Parkinson’s.

The revelations that top federal scientists believe the government has stonewalled an investigation has infuriated some of those affected and their families, who are demanding a response.

“I really feel alarmed but not surprised at how the information is being dismissed. And I feel that there is a moral and ethical responsibility for other officials to step in,” said Stacie Quigley Cormier, whose 23-year-old daughter Gabrielle is suffering from a neurological disorder that has left her with muscle loss and shaking. “I don’t feel like they’ve forgotten about us. I feel like they’ve intentionally pretended to forget about us and that there’s nothing to see here,” she said in a phone interview...

 

Cecco, L. (2022, January 2). Whistleblower warns baffling illness affects growing number of young adults in Canadian province. Yahoo. https://www.yahoo.com/news/whistleblower-warns-baffling-neurological-illness-110015762.html

A whistleblower in the Canadian province of New Brunswick has warned that a progressive neurological illness that has baffled experts for more than two years appears to be affecting a growing number of young people and causing swift cognitive decline among some of the afflicted.

Speaking to the Guardian, an employee with VitalitĂ© Health Network, one of the province’s two health authorities, said that suspected cases are growing in number and that young adults with no prior health triggers are developing a catalog of troubling symptoms, including rapid weight loss, insomnia, hallucinations, difficulty thinking and limited mobility.

The official number of cases under investigation, 48, remains unchanged since it was first announced in early spring 2021. But multiple sources say the cluster could now be as many as 150 people, with a backlog of cases involving young people still requiring further assessment.


WHAT IS CAUSING THIS CRISIS

What could be causing the protein misfolding? It will be impossible to identify the causal agents without substantial investigation but I do have to wonder about the frameshifting effects of mRNA vaccines that do produce misfolded proteins, as reported here in the Guardian:

Pinkstone, J. (2023, December 6). Science Correspondent 6 December 2023 One in four who had Pfizer Covid jabs experienced unintended immune response https://www.telegraph.co.uk/news/2023/12/06/mrna-jabs-modena-pfizer-quarter-unintended-response/
mRNA vaccines were affected by the glitch but no adverse effects were created, Cambridge researchers say. More than a quarter of people injected with mRNA Covid jabs suffered an unintended immune response created by a glitch in the way the vaccine was read by the body, a study has found.

No adverse effects were created by the error, data show, but Cambridge scientists found such vaccines were not perfect and sometimes led to nonsense proteins being made instead of the desired Covid “spike”, which mimics infection and leads to antibody production.

mRNA jabs, such as the ones created by Moderna and Pfizer, use a string of genetic material to tell the body to create a specific protein that safely imitates an infection.

Research in the field, spanning decades, had been slow work. It often stalled because RNA itself is often attacked by the body as a foreign invader.
 

RELEVANT RESEARCH

The reason the mRNAs produce frameshifting has been pinpointed as resulting from the substitution of a naturally occurring ribonucleotide with a synthetic one in order to reduce immunogenicity. This substitution affects "the fidelity of mRNA translation" thereby causing these frameshifting errors:

Mulroney, T.E., Pöyry, T., Yam-Puc, J.C. et al. N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. Nature (2023). https://doi.org/10.1038/s41586-023-06800-

in vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IVT mRNAs are transfected into target cells, where they are translated into recombinant protein, and the biological activity or immunogenicity of the encoded protein exerts an intended therapeutic effect1,2.

Modified ribonucleotides are commonly incorporated into therapeutic IVT mRNAs to decrease their innate immunogenicity3,4,5, but their effects on mRNA translation fidelity have not been fully explored. Here we demonstrate that incorporation of N1-methylpseudouridine into mRNA results in +1 ribosomal frameshifting in vitro and that cellular immunity in mice and humans to +1 frameshifted products from BNT162b2 vaccine mRNA translation occurs after vaccination.

The +1 ribosome frameshifting observed is probably a consequence of N1-methylpseudouridine-induced ribosome stalling during IVT mRNA translation, with frameshifting occurring at ribosome slippery sequences. However, we demonstrate that synonymous targeting of such slippery sequences provides an effective strategy to reduce the production of frameshifted products. Overall, these data increase our understanding of how modified ribonucleotides affect the fidelity of mRNA translation, and although there are no adverse outcomes reported from mistranslation of mRNA-based SARS-CoV-2 vaccines in humans, these data highlight potential off-target effects for future mRNA-based therapeutics and demonstrate the requirement for sequence optimization.

See also

Tursi, N.J. & Weinder, D.B. (2023, December). Modified messenger-RNA components alter the encoded protein. Nature. https://www.nature.com/articles/d41586-023-03787-9

Of course, we don't KNOW that the frameshifting effect of the mRNAs is causing these problems in Canada. 

Why would New Brunswick have such a clustering effect? If the mRNA vaccines were the cause wouldn't we see the effect more widely distributed? Of course, it is feasible that a bad batch led to concentrated effects but without investigation there is no way of testing this hypothesis.

Other neurodegenerative impacts of the mRNA vaccines have been identified beyond the frameshifting hazard:
  • Idrees D, Kumar V. SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. Biochem Biophys Res Commun. 2021 May 21;554:94-98. doi: 10.1016/j.bbrc.2021.03.100. Epub 2021 Mar 24. PMID: 33789211; PMCID: PMC7988450.
  • Tetyana P. Buzhdygan, Brandon J. DeOre, Abigail Baldwin-Leclair, Trent A. Bullock, Hannah M. McGary, Jana A. Khan, Roshanak Razmpour, Jonathan F. Hale, Peter A. Galie, Raghava Potula, Allison M. Andrews, Servio H. Ramirez, The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier, Neurobiology of Disease, 146, 2020 https://doi.org/10.1016/j.nbd.2020.105131. "Blood-brain barrier function is negatively affected by SARS-CoV-2 spike protein subunits. Brain endothelial cells show a distinct pro-inflammatory response when exposed to various SARS-CoV-2 spike protein subunits." 

As I've already pointed out, we simply don't know but the Canadian government's efforts to shut down investigation, as criticized by their own scientists, raises red flags.
 
READ MORE

Wednesday, June 19, 2024

The Sheep may NOT graze safely! NRC Retreat on Nuclear Power Safety

A couple of days back I posted on the collapse of public purpose as institutional interests disregard the public's economic and cultural welfare, as well as political rights: http://majiasblog.blogspot.com/2024/06/the-end-of-public-purpose-and-collapse.html

Here is a prime example: The "retreat on nuclear power safety" by the NRC is extraordinarily concerning given US aged nuclear reactor infrastructure and persistent onsite safety risks:

UCS: “ADVANCE Act” Actually a Retreat on Nuclear Power Safety: Statement by Edwin Lyman, Nuclear Power Safety Director, Union of Concerned Scientists, UCS press release, Jun 17, 2024. https://www.ucsusa.org/about/news/advance-act-retreat-nuclear-power-safety.

Statement by Dr. Edwin Lyman, Director of Nuclear Power Safety at the Union of Concerned Scientists (UCS) on the Accelerating Deployment of Versatile, Advanced Nuclear for Clean Energy Act (ADVANCE Act) addition to legislation to reauthorize federal firefighter programs:

“It’s extremely disappointing that, without any meaningful debate, Congress is about to erase 50 years of independent nuclear safety oversight by changing the NRC’s mission to not only protect public health and safety but also to protect the financial health of the industry and its investors. Just as lax regulation by the FAA—an agency already burdened by conflicts of interests—can lead to a catastrophic failure of an aircraft, a compromised NRC could lead to a catastrophic reactor meltdown impacting an entire region for a generation.”


“Make no mistake: This is not about making the reactor licensing process more efficient, but about weakening safety and security oversight across the board, a longstanding industry goal. The change to the NRC’s mission effectively directs the agency to enforce only the bare minimum level of regulation at every facility it oversees across the United States.”

 “Passage of this legislation will only increase the danger to people already living downwind of nuclear facilities from a severe accident or terrorist attack, and it will make it even more difficult for communities to prevent risky, experimental reactors from being sited in their midst.”]


RELATED POSTS

http://majiasblog.blogspot.com/2016/12/eisenhowers-warning-and-regulatory.html

 

Tuesday, June 4, 2024

The End of Public Purpose and the Collapse of Public Trust: The Sheep Cannot Safely Graze

 

I've been following the appalling revelations of misconduct spilling forth from the House’s Select Subcommittee on the Coronavirus Pandemic.

Among the most grievous findings was evidence that Fauci's close associate at NIAID, Morens, sought to evade public transparency requirements of the Freedom of Information Act by communicating on private emails and by misspelling words to avoid search inquiries.

See McKay, B. (2024, June 3). Anthony Fauci Defends Federal Covid Response. The Wall Street Journal https://www.wsj.com/politics/anthony-fauci-to-appear-before-house-committee-on-covid-06142639?st=jdsgppunjcpdd8y&reflink=desktopwebshare_permalink

What were they seeking to hide?

It has become clear that one bit of information that was selectively hidden concerned the royalty payments made by Pfizer and Moderna directly to NIH and NIAID, which personally enriched scientists affiliated with those agencies. 

That revenue stream reported to be $710 million to the NIH and $690 to NIAID between 2021 and 2023 is a DIRECT CONFLICT OF INTEREST where personal gain ensures regulatory capture and undermines public purpose.

While being personally enriched by royalty payments, Fauci and his "cronies" (this is the only apt term) deliberately suppressed information about pandemic origins and the efficacy of vaccines and other treatments.

Why was the "lab leak" hypothesis systematically denied and symbolically rendered radioactive by labeling it "racist"?

Why was the mRNA vaccine platform elevated and all information regarding its failures and hazards suppressed or labeled "misinformation" and marginalized?

Why were all critics de-platformed?

What was the intent that drove this unprecedented totalitarianism?

Today I was reading a seminal piece on risk by Brian Wynne titled, "May the Sheep Safely Graze? A Reflexive View of the Expert-Knowledge Divide" and pondering the scale of debasement of expert, institutional knowledge in pandemic governance.

Wynne observed that "Institutions which can be seen to be reconstructing history so as to confirm their own blamelessness whilst attempting to manufacture public trust and legitimation are prima facie likely to be undermining public trust rather than enhancing it" (p. 51)   

This passage struck me as I observed Fauci and other bureaucrats decry the decline in public trust in so-called democratic institutions such as NIH, NIAID, and the WHO.

These institutions have sought to centralize power over people's bodies and communications at an unprecedented level. 

These institutions have deceived publics by withholding vital information that undermined their draconian directives and mandates.

These institutions have deleted and otherwise hidden information that is legally required to be recorded and made available to public queries.

For example, as Shellenberg reports:

there was never definitive evidence that the vaccines would prevent transmission. In December 2020, the FDA determined that “data are not available to make a determination about how long the vaccine will provide protection, nor is there evidence that the vaccine prevents transmission of SARS-CoV-2 from person to person.”

The mRNA failures were documented before the OSHA mandate.

I was carefully following news reports of "breakthrough" infections and have documentation from early in 2021 that the vaccines were not effective in preventing contagion and transmission. Nonetheless, mandates were rolled out and adverse reactions censored and denied, erased from social media by being categorized as "mal-information" ("true" information regarded as politically non-expedient) by the new self-appointed guardians of truth (many of which, I'm sorry to write, were academics).

The medical establishment proved its cowardice in failing to recognize and report adverse events, as I have documented many times on this blog. For instance, my health insurance company directed me NOT to go to the hospital despite severe chest pressure and heart pain that lasted 5 days after my first moderna vaccine.

The decline in public trust in public institutions is a direct result of the dispensation of public purpose by those institutions.

Authoritarianism, censorship, and the de-platforming of opposition and criticism are the ailments that are delivering skepticism and resistance.

Truth and reconciliation are the only way forward but sadly and perhaps not accidentally, these issues of institutional corruption have been politicized and coded "red" so that a factionalized public is unable to launch a concerted campaign demanding truth and reform.

Technocracy wins. Public trust disappears. Democracy fades. The sheep cannot safely graze.