Thursday, September 7, 2023

Hazards of mRNA Vaccine Platform Reviewed

50% of my household suffered severe adverse events from the Moderna vaccine. I only got the vaccine because I was threatened with being fired. See my post here:http://majiasblog.blogspot.com/2021/12/this-is-not-disinformation-lot-030b21a.html

The consequences for our compliance with this extortion haunt us today.

Moreover, we know many, many people who suffered auto-immune disease conditions after taking mRNA vaccines. We also know of two people who died from their "vaxxes." I've reviewed the failed cost-benefit analysis previously at this blog.

I have spent the last 3 years trying to understand what happened. I've learned that there are at least 4 known problems with the mRNA platform:

  • The spike protein payload
  • The lipid "nanoparticle" delivery system
  • The synthetic mRNA - N1-methylpseudouridine used in mRNA
  •  Contaminants/Adulterants 

Spike protein is dangerous in and of itself. Lipid nanoparticle encased instructions for your body engineering spike can persist for an unknown length of time and get distributed across your body and bioaccumulate in organs!  Worse - the lipid nanoparticles are themselves highly toxic!

LIPID NANOPARTICLE DELIVERY SYSTEM

I highly recommend the informative video here regarding nature and hazards of lipid nanoparticles used in mRNA vaccinations by Dr Robert Malone, whose work with mRNA makes him a very legitimate authority on this subject:

https://open.substack.com/pub/rwmalonemd/p/lipid-nanoparticles-a-regulatory?r=q89bo&utm_campaign=post&utm_medium=web

RELATED RESEARCH

Parhiz, H. et al., (2022). Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE). Journal of Controlled Release, 344, 50-61.

Current nucleoside-modified RNA lipid nanoparticle (modmRNA-LNP) technology has successfully paved the way for the highest clinical efficacy data from next-generation vaccinations against SARS-CoV-2 during the COVID-19 pandemic. 

However, such modmRNA-LNP technology has not been characterized in common pre­ existing inflammatory or immune-challenged conditions, raising the risk of adverse clinical effects when administering modmRNA-LNPs in such cases. 

Herein, we induce an acute-inflammation model in mice with lipopolysaccharide (LPS) intratracheally (IT), 1 mg kg-1, orintravenously (IV), 2 mg kg-1, and then IV administer modmRNA-LNP, 0.32 mg kg-1, after 4 h, and screen for inflammatory markers, such as pro­ inflammatory cytokines. ModmRNA-LNP at this dose caused no significant elevation of cytokine levels in naive mice. 

In contrast, shortly after LPS immune stimulation, modmRNA-LNP enhanced inflammatory cytokine responses, Interleukin-6 (IL-6) in serum and Macrophage Inflammatory Protein 2 (MIP-2) in liver significantly. 

Our report identifies this phenomenon as inflammation exacerbation (IE), which was proven to be specific to the LNP, acting independent of mRNA cargo, and was demonstrated to be time- and dose-dependent. Macrophage depletion as well as TLR3 -/- and TLR4-/- knockout mouse studies revealed macrophages were themmune cells involved or responsible for IE. Finally, we show that pretreatment with anti-inflammatory drugs, such as corticosteroids, can partially alleviate IE response in mice. Our findings characterize the importance of LNP­ mediated IE phenomena in gram negative bacterial inflammation, however, the generalizability of modmRNA­ LNP in other forms of chronic or acuteinflammatory and immune contexts needs to be addressed.

SYNTHETIC mRNA 

According to a 2020 study (doi.org/10.1105/tpc.19.00639) the biological relevance of pseudouridine in mRNA remains unclear so downstream effects are not yet mapped:

Mingjia Chen , Claus-Peter Witte, A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation, The Plant Cell, Volume 32, Issue 3, March 2020, Pages 722–739, https://doi.org/10.1105/tpc.19.00639 

This same study observes a risk of toxicity from pseurdouridine: Compromising pseudouridine catabolism leads to strong pseudouridine accumulation and increased ΨMP content. ΨMP is toxic, causing delayed germination and growth inhibition. More Research Needed to Assure Safety, Especially with Cumulative Exposures. 

SPIKE PROTEIN PAYLOAD ISSUES

Scientists from the Salk institute that found that the spike protein alone, in the absence of the rest of the virus, can cause damage to endothelial cells? Here is the citation and the link to the press release for your reference

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
Yuyang Lei , Jiao Zhang , Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin , Yoshitake Cho , Leonardo Andrade , Gerald S. Shadel , Mark Hepokoski, Ting Lei, Hongliang Wang, Jin hang, Jason X.-J. Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang, Zu-Yi Yuan, John Y-J. Shyy Originally published31 Mar 2021https://doi.org/10.1161/CIRCRESAHA.121.318902Circulation Research. 2021;128:1323–1326

Another study finds that the spike protein, detached from the rest of the virus, elicits cell signalling in human cells, which "may promote pulmonary vacular remodeling and PAH [pulmonary arterial hypertension] as well as other cardiovascular complications":

Yuichiro J. Suzuki1,* and Sergiy G. Gychka SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines. Vaccines 2021, 9(1), 36; https://doi.org/10.3390/vaccines9010036

CONTAMINANTS

Dr. Malone, in the video linked above, explains how failures in mRNA vaccine manufactoring are resulting in concerning DNA contamination. The production process is not "clean," as an example from Japan illustrates.

August 28, 20213:38 Two die in Japan after shots from suspended Moderna vaccines - Japan govt Reuters https://www.reuters.com/business/healthcare-pharmaceuticals/two-die-japan-after-shots-suspended-moderna-vaccines-japan-govt-2021-08-28/

TOKYO, Aug 28 (Reuters) - Two people died after receiving Moderna Inc (MRNA.O) COVID-19 vaccine shots that were among lots later suspended following the discovery of contaminants, Japan's health ministry said on Saturday.

 

RELATED POSTS

http://majiasblog.blogspot.com/2022/05/mrna-vaccines-linked-to-higher-cardio.html

http://majiasblog.blogspot.com/2022/04/fda-shuts-out-its-own-experts-in.html

http://majiasblog.blogspot.com/2022/03/thanatopolitics-and-vaccine-apartheid.html

http://majiasblog.blogspot.com/2021/08/what-is-going-on-no-public-health.html

http://majiasblog.blogspot.com/2021/06/spike-protein-blues.html

http://majiasblog.blogspot.com/2021/06/approval-mandatory-vaccine-mandates-for.html 


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