Sunday, March 3, 2013

Might Ionizing Radiation Contribute to Autism?


I read a blog post on cesium and psychiatric disorders last night. It reminded me of a recent study published in The Lancet on psychiatric disorders and single base mutations in genes affecting calcium channel operations

Might ionizing radiation contribute to autism (and ADHD and schizophrenia) by creating single base mutations in genes affecting calcium channel operations?

Might radiocesium be a primary culprit because it mimics potassium, which is involved in calcium channel operations?

Below you will see the post by Mikkai suggesting the link between mental illness and radiocesium. 

Then I present newly published research in The Lancet finding point mutations in genes regulating calcium channel operations in a genomic study of people with psychiatric diseases, such as autism, ADHD, and schizophrenia:



Mikkai: Nuclear Industry: Mental illness and Heart diseases http://tekknorg.wordpress.com/2013/02/24/nuclear-industry-mental-illness-and-heart-diseases/

[Excerpted] The Principle of excitation of nerve cells / action potential: A vital function of the Axons is the potassium charge / ion, the sodium pump flow / unction depends on it.

Of which depends the household of the neurotransmitters in the brain! And HOW YOU deal with a situation. And ultimatively, WHO you are.


Cesium 137 mimics potassium.

Ionizing radiation and schizophrenia: http://www.researchgate.net/publication/7496184_Whether_ionizing_radiation_is_a_risk_factor_for_schizophrenia_spectrum_disorders
PAGE 61: http://life-upgrade.com/DATA/chernobylebook.pdf

Radionuclides are the cause for the epidemic explosion of heart diseases and mentall illness worldwide, especially above the equator.This is where Cesium 137 goes...

Majia Here: The post includes a visual that is helpful for understanding the  brain's potassium charges.

 

Majia here: Recently the Psychiatric Genomics Consortium found high numbers of single base mutations in genes regulating calcium balances in the brain among people with autism, schizophrenia, and ADHD. The original article was published in The Lancet and can be seen here

A brief description can be found here: Shared Genes May Link ADHD, Autism, and Depression http://www.webmd.com/add-adhd/news/20130227/shared-genes-may-link-adhd-autism-and-depression

[Excerpted] the Psychiatric Genomics Consortium scanned the genes of more than 33,000 people suffering from these disorders and nearly 28,000 people without such issues. This is the largest study of the genetics of psychiatric illness yet conducted, the researchers said.

Smoller's group found four gene areas that all overlapped with the five disorders, two of which regulate calcium balance in the brain.

Majia here: The study found SINGLE NUCLEOTIDE POLYMORPHISMS, or variations in a single DNA base, particularly in genes associated with calcium channel functions

Calcium channel functions involve potassium:

Faber, E. S. & Sah, P. Calcium-Activated Potassium Channels: Multiple Contributions to Neuronal Function http://nro.sagepub.com/content/9/3/181.abstract
[Excerpted] Calcium-activated potassium channels are a large family of potassium channels that are found throughout the central nervous system and in many other cell types. These channels are activated by rises in cytosolic calcium largely in response to calcium influx via voltage-gated calcium channels that open during action potentials. Activation of these potassium channels is involved in the control of a number of physiological processes from the firing properties of neurons to the control of transmitter release. These channels form the target for modulation for a range of neurotransmitters and have been implicated in the pathogenesis of neurological and psychiatric disorders. Here the authors summarize the varieties of calcium-activated potassium channels present in central neurons and their defining molecular and biophysical properties.[end quote]

Majia here: Ok so potassium levels and operations are critical to calcium channel functions, and disruptions have been linked to psychiatric diseases.

People with autism, schizophrenia, and ADHD have more single nucleotide polymorphisms in genes related to calcium channel operations. 

Single Nucleotide Polymorphisms are point MUTATIONS. Where do the mutations come from?

Many environmental carcinogens can produce DNA damage, such as point mutations, but IONIZING RADIATION is among the most powerful force capable of disrupting DNA.

Here is a study that has found a direct correlation with occupational exposure to ionizing radiation and DNA polymorphisms:

Angelini, et al. (2005 )Micronuclei in humans induced by exposure to low level of ionizing radiation: influence of polymorphisms in DNA repair genes' Mutation Research, Volume 570, Issue 1 105–117. http://www.sciencedirect.com/science/article/pii/S0027510704004452

Abstract

Understanding the risks deriving from protracted exposure to low doses of ionizing radiation has remarkable societal importance in view of the large number of work settings in which sources of IR are encountered. To address this question, we studied the frequency of micronuclei (MN), which is an indicator of DNA damage, in a population exposed to low levels of ionizing radiation and in matched controls. In both exposed population and controls, the possible influence of single nucleotide polymorphisms in XRCC1, XRCC3 and XPD genes on the frequency of micronuclei was also evaluated. 

We also considered the effects of confounding factors, like smoking status, age and gender. The results indicated that MN frequency was significantly higher in the exposed workers than in the controls [8.62 ± 2.80 versus 6.86 ± 2.65; P = 0.019]. Radiological workers with variant alleles for XRCC1 or XRCC3 polymorphisms or wild-type alleles for XPD exon 23 or 10 polymorphisms showed a significantly higher MN frequency than controls with the same genotypes. Smoking status did not affect micronuclei frequency either in exposed workers or controls, while age was associated with increased MN frequency in the exposed only. In the combined population, gender but not age exerted an influence on the yield of MN, being higher in females than in males. 

Even though there is a limitation in this study due to the small number of subjects, these results suggest that even exposures to low level of ionizing radiation could have genotoxic effects and that XRCC3, XRCC1 and XPD polymorphisms might contribute to the increased genetic damage in susceptible individuals occupationally exposed to chronic low levels of ionizing radiation. For a clear conclusion on the induction of DNA damage caused by protracted exposure to low doses of ionizing radiation and the possible influence of genetic polymorphism in DNA repair genes larger studies are needed.

Majia here: What I've tried to assemble is evidence that suggests that the DNA mutations that are now being linked to psychiatric diseases MAY be caused by ionizing radiation, among other environmental toxins, and that the potassium mimicking properties of radiocesium make it a likely culprit. 

The body's misrecognition of radiocesium (as if it were potassium) may cause it to distribute radiocesium widely, including in the brain, where it may cause random DNA point mutations, disrupting neurological functions.

 

Chemical endocrine disruptors have also been figured http://majiasblog.blogspot.com/2013/02/state-of-science-of-endocrine.html

  

   

1 comment:

  1. Majia, you may like this one, original research by me

    Kind of unrelated, but heres the tie in. The Peshtigo fire, the worst ever, affected Kewaunee nuke plant area. and the powers that be lie to us constantly. take care of yourself, prep for the worst, and do not expect help from the gov when you most need it.

    I think I tied more events together to this 1871 asteroid attack than anyone in history.

    Check it out.

    http://nukeprofessional.blogspot.com/2013/03/meteor-coincidence-methinks-not.html

    ReplyDelete