Thursday, January 26, 2012

Thyroid problems, Pituitary Gland tumors, Parkinson’s disease, Autism and Allergies.



Want to bet these “low” levels of ionizing radiation contribute directly to these diseases?

DNA analysis of people with autism finds microdeletions of DNA. No clear idea why. http://cirge.stanford.edu/documents/CNV%20workshop/CNV%20Kumar.pdf

Parkinsons has already been tied to pesticide use–it is an environmental disease even if one has more or less personal susceptibility because of particular alleles or general level of health.

Ionizing radiation is much more effective than chemicals in breaking chemical bonds. 

Might ionizing radiation play a role in disrupting dopamine production and receptors in Parkinsons?

Perhaps damage to thyroid and pituitary glands by radiation plays a role? Maybe the immune system is compromised by ionizing radiation?

Certainly, we know that the auto-immune problems associated with allergies are increasing in the western industrial world. No known reason why, despite plenty of hypotheses. http://www.aafa.org/display.cfm?id=9&sub=30


And pituitary tumors are now being recognized as an important source of endocrine disease and migraine.

The potential for ionizing radiation to play a role in these diseases seems obvious.

But through what mechanisms? How might ionizing radiation contribute to such a wide range of diseases?

Full spectrum autism serves as an example illustrating how low-level ionizing radiation might possibly weaken the body and biological repair mechanisms to the point that symptoms emerge, particularly when combined with other environmental insults.

The microdeletions found in autism are an obvious source of trouble if you get enough of them.

Ionizing radiation is called ionizing because it breaks chemical bonds such as DNA.

As cited above and documented in numerous other studies, people with autism have unusually high levels of microdeletions.

Too many microdeletions could cause all sorts of biological symptoms to go haywire.

At another level of analysis one could consider another symptom that has been linked to autism.

People with autism have low levels of natural killer cells (NKcells).

NK cells are critical to the body's defense and repair systems.

One form of NK cells, CD 56, has been demonstrated to be highly sensitive to disruption by ionizing radiation. 

Research has established that NK CD 56 cells are disrupted in people with autism. See the citations and abstracts below.

These links I’ve established here between ionizing radiation and disease are very suggestive.

Research needs to address the role of ionizing radiation in damaging health by disrupting NK cells and by causing microdeletions and other translational problems in DNA.

Research should also address how ionizing radiation, not just chemicals, disrupts the body's endocrine systems by damaging the thyroid and pituitary gland.

Very little research on autism and other diseases have pursued these trajectories.

Most environmental research on disease focuses exclusively on chemicals. Although petro and other synthetic chemicals no doubt play an important role in adversely impacting human health, we have neglected the most mutagenic force of all: human created ionizing radiation. (see Wikipedia for mutagenic properties http://en.wikipedia.org/wiki/Mutagen).

I keep asking why?


Autism References

CD 56 NK cells are highly sensitive to ionizing radiation

The conclusion "CD56 (bright) subset of NK cells and this subpopulation was considered as the most radiosensitive one." was found in this article: Doris Vokurková a, Ji_rina Vávrová b, Ji_rí _Sinkora c, Alena Stoklasová a, Václav Bláha b, Martina _Rezá_cová a (2010). Radiosensitivity of CD3_CD8þCD56þ NK cells Radiation Measurements 45 (2010) 1020e1023

The connection to autism for CD 56 cells was found in this article:ABSTRACT: “children with autism found to have abnormalities in function of NK cells, Immune related abnormalities have repeatedly been reported in autism spectrum disorders (ASD), including evidence of immune dysregulation and autoimmune phenomena. NK cells may play an important role in neurodevelopmental disorders such as ASD. Here we performed a gene expression screen and cellular functional analysis on peripheral blood obtained from 52 children with ASD and 27 typically developing control children enrolled in the case-control CHARGE study. RNA expression of NK cell receptors and effector molecules were significantly upregulated in ASD. Flow cytometric analysis of NK cells demonstrated increased production of perforin, granzyme B, and interferon gamma (IFNc) under resting conditions in children with ASD (p < 0.01). Following NK cell stimulation in the presence of K562 target cells, the cytotoxicity of NK cells was significantly reduced in ASD compared with controls (p < 0.02). Furthermore, under similar stimulation conditions the presence of perforin, granzyme B, and IFNc in NK cells from ASD children was significantly lower compared with controls (p < 0.001). These findings suggest possible dysfunction of NK cells in children with ASD. Abnormalities in NK cells may represent a susceptibility factor in ASD and may predispose to the development of autoimmunity and/or adverse neuroimmune interactions during critical periods of development. Altered gene expression and function of peripheral blood natural killer cells in children with autism.
Brain, Behavior, and Immunity, Volume 23, Issue 1, January 2009, Pages 124-133


ALSO in


ABSTRACT: "Measurement of natural killer (NK) cell activity in blood samples of autistic children (n=1027) revealed that 45% of the subjects exhibited low NK cell activity compared to the controls (n=113). The correlation of this finding with low intracellular glutathione, IL-2 and IL-15 levels may indicate the underlying cause for NK cell dysfunction in a subset of autistic children [11]. Gene expression of perforin, granzyme B and interferon-γ (IFNγ) in peripheral blood NK cells of ASD patients (n=52) was decreased compared to the control group (n=27) under similar stimulation conditions, indicating depressed cytotoxicity [12 Mast cell activation and autism

Theoharis C. Theoharides a,b,c,d,e,⁎, Asimenia Angelidou a,e, Konstantinos-Dionysios Alysandratos a,e, Bodi Zhang a,b, Shahrzad Asadi a, Konstantinos Francis f, Elena Toniato g, Dimitrios Kalogeromitros (2011) Biochimica et Biophysica Acta

9 comments:

  1. I highly recommend desiccated thyroid supplements .It is the only way for me.I can't be without it..

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  2. 85% of Autistic people have antibodies to L and Z (lutein and xanthene), which explains why they might attack the pituitary gland, as well as the eyes, and have no lutein in the skin, leading to depletion of chlorophyll, and xanthine oxidase...increased urea....cravings for arginine-peanuts...or cravings for cellulose-coal, cotton, wood. It also explains why theri eye are so sensitive and vision distorted...causing reversal of brainflow-read the research article about the people who wore right-left vision reversal lenses and what happened to their brain--they became autistic...but they were able to recover since they were not trying to metabolize themselves!

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  3. The reason for the antibodies-when people come into this world naturally they are exposed to Lutein in the corpus luteium...but with invitro and fertility drug, there is no exposure prior to conception....this is why autistic women hemmorhage when they ovulate-they are attacking their corpus luteium....just my opinion.

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  4. Taking chlorophyll helps...without lutein you can't have chlorophyll so you have to take a supplement....and peanutbutter...prism lenses.....lower oxygen and higher co2....prevents increased ammonia and oxygen toxicity.

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  5. Look at the functions of the things they are lacking: what is copper for? Lutein? chlorophyll? xanthene? The Kreb cycle cannot work in these people.

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  6. This comment has been removed by a blog administrator.

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  7. Hi there! Keep it up! This is a good read. I will be looking forward to visit your page again and for your other posts as well. Thank you for sharing your thoughts about pituitary tumor. I am glad to stop by your site and know more about pituitary tumor.
    Most tumours are benign but are quite serious because of their position close to important brain structures.
    Because the pituitary gland is responsible for the production of hormones key to proper body function, tumors often interfere with this production—either by limiting the amount of hormone produced or generating excessive amounts. Growth hormone (regulates body height and structure), prolactin (controls lactation, or milk production), sex hormones (control the menstrual cycle and other sexual functions), thyroid gland hormones (control the thyroid gland), adrenal gland hormones, and vasopressin (a hormone involved in water and electrolyte balance) are all examples of hormones that can be affected. Growing tumors can also push on surrounding structures, often resulting in headaches, behavioral changes, and vision problems.

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  8. Thanks for sharing! The exact cause of pituitary tumor is not known. Treatment usually includes surgery to remove the tumor, though in some cases drug therapy may be used to reduce tumor size. Replacement hormone therapy is often prescribed following surgery and/or radiation.

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  9. I appreciate all of the information that you have shared. Thank you for the hard work!
    A pituitary tumor is an abnormal growth on the pituitary gland, a small pea-sized organ located at the base of the brain behind the bridge of the nose.

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